Suisun Slough is a major tidal waterway providing access to the expansive Suisun Marsh, the largest contiguous estuarine marsh in the United States, covering 84,000 to 116,000 acres of conservation land. The primary and recommended public access point for paddlers is the Suisun City Marina and Boat Ramp, located at 1250 Kellogg Street. This facility offers two concrete launch ramps and three floating high freeboard docks, with the slope of the boarding piers changing with the tide. A large parking lot is available, with a $5 fee for vehicles with trailers; parking is allowed for up to 72 hours. An older launch behind the civic center is no longer maintained and is overgrown. The marina area provides amenities including a restroom with flush toilets, picnic tables, a drinking fountain, and benches, with restaurants and shops within walking distance in the historic waterfront district. The path of travel from parking to the launch is flat and paved.

Paddling here is a tidal experience with significant safety considerations. Mudflats become exposed during low tides, which can strand boaters. Afternoon winds are frequent and can make returning to the launch difficult. The slough's waters are generally calm and easy, connecting to a network of channels including Peytonia Slough and leading eventually toward San Pablo Bay and San Francisco Bay. The surrounding marshes are filled with wildlife, particularly birds along the Pacific Flyway, making it a notable destination for bird-watching from the water. The area is part of the Grizzly Island Wildlife Area complex, and some units, like the Grey Goose Unit, are only accessible by boat from Suisun Slough. Seasonal hunting is allowed within the marsh, which paddlers should be aware of. The overall character is peaceful and relaxing, with long, flat vistas and Mount Diablo visible in the distance. Due to the tidal nature and frequent winds, careful planning around tide stages and weather forecasts is essential for a safe trip.