The North Fork Edisto River is a scenic blackwater river in central South Carolina. It originates in Saluda County and flows southeast for approximately 66 miles before joining the South Fork to form the main stem of the Edisto River near Branchville. The North Fork is part of the larger Edisto River Basin watershed.

Paddlers will find a diverse experience on the North Fork, with sections transitioning from developed areas with backyard docks to more remote, primeval surroundings. The river is mostly narrow and winding, requiring skilled maneuvering around fallen trees and potential portages. Difficulty ranges from flatwater to Class I rapids, with some sections reaching Class II-III, making it suitable for intermediate to experienced paddlers. Popular paddling sections include the 38-mile stretch from Poole's Mill Landing to Glover Street Landing in Orangeburg, and the final 2.2-mile segment from Kill Kare Landing to the confluence with the South Fork.

The river is best paddled in spring and fall when water levels are optimal and temperatures are moderate. The North Fork's ecosystem supports diverse flora and fauna typical of South Carolina's blackwater rivers. Paddlers may encounter cypress and tupelo trees, various wading birds, and occasionally alligators in the lower sections.

Key access points include Poole's Mill Landing near the river's origin, Jones Bridge Landing at mile 6.8, Carson Park at mile 10.2, Slab Landing at mile 17.4, and Glover Street Landing in downtown Orangeburg. The final public access point is Kill Kare Landing, about 2 miles upstream from the confluence.

Historically, the North Fork Edisto River played a role in early settlement and agriculture in the region. Today, it offers a unique paddling experience that showcases the natural beauty of South Carolina's Lowcountry. Safety considerations include being prepared for fallen trees across the channel, checking water levels before trips, and being aware of private property along the banks. Multi-day trips are possible, with primitive camping available at designated sites.

The North Fork Edisto River provides paddlers with a chance to explore a less-developed waterway, offering a serene escape into nature and a glimpse of South Carolina's rich riverine landscapes.